BSCL2/Seipin Deficiency in Heart Causes Energy Deficit and Heart Failure via Inducing Excessive Lipid Catabolism
H. Zhou, J. Li, H. Su, J. Li, T. A. Lydic, M. E. Young, W. Chen
This study shows that BSCL2 deficiency in the heart causes heart failure through excessive lipid catabolism, reduced energy reserves, and ATP levels, which can be mitigated by inhibiting fatty acid oxidation or high-fat diet.
bioRxiv · Jun 7, 2021 · PreprintPhysiology