Author

T. A. Lydic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. E. Mead· 1 shared C. Cady· 1 shared E. A. Bates· 1 shared G. A. Graf· 1 shared H. A. Clarke· 1 shared H. Su· 1 shared H. Zhou· 1 shared J. Li· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPhysiology

A. E. Mead

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Author profile →

2 papers

Recent·Most cited

Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice

M. M. Zelows, C. Cady, N. Dharanipragada, A. E. Mead, Z. A. Kipp, E. A. Bates, V. Venkateshwari, R. Banerjee, S.-H. Park, N. R. Shelman, H. A. Clarke, T. R. Hawkinson, T. Medina, R. C. Sun, T. A. Lydic, , R. N. Helsley

This study shows that liver-specific deletion of CPT1a in mice leads to reduced DHA-containing phospholipids and sexually dimorphic liver disease, with females showing more severe effects.

bioRxiv · Aug 17, 2023Physiology

BSCL2/Seipin Deficiency in Heart Causes Energy Deficit and Heart Failure via Inducing Excessive Lipid Catabolism

H. Zhou, J. Li, H. Su, J. Li, T. A. Lydic, M. E. Young, W. Chen

This study shows that BSCL2 deficiency in the heart causes heart failure through excessive lipid catabolism, reduced energy reserves, and ATP levels, which can be mitigated by inhibiting fatty acid oxidation or high-fat diet.

bioRxiv · Jun 7, 2021 · PreprintPhysiology