The elasticity of individual protocadherin 15 molecules implicates cadherins as the gating springs for hearing
T. F. Bartsch, F. E. Hengel, A. Oswald, G. Dionne, I. V. Chipendo, S. S. Mangat, M. El Shatanofy, L. Shapiro, U. Mueller, A. J. Hudspeth
The paper shows that individual PCDH15 molecules act as entropic springs, contributing to the gating mechanism of hair cell transduction channels by modulating stiffness through tension and Ca2+ concentration.
bioRxiv · Dec 20, 2018Biophysics