Selectivity Filter Instability Dominates the Low Intrinsic Activity of the TWIK-1 K2P K+ Channel
E. Nematian-Ardestani, M. F. Abd-Wahab, F. C. Chatelain, H. Sun, M. Schewe, T. Baukrowitz, S. J. Tucker
This study identifies the instability of the selectivity filter (SF) gate in TWIK-1 K2P channels as the primary cause of their low intrinsic activity.
bioRxiv · Dec 2, 2019Biophysics