Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled Receptors
A. N. Dates, D. T. D. Jones, J. S. Smith, M. A. Skiba, M. F. Rich, M. M. Burruss, A. C. Kruse, S. C. Blacklow
The paper profiles tethered agonist (TA) signaling in all 33 human aGPCRs using a platform across assays, revealing heterogeneous responses and aligning with AlphaFold2 predictions.
bioRxiv · Jul 14, 2022Biochemistry