Author

M. A. Skiba

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. C. Kruse· 3 shared G. R. Nemeth· 2 shared J. D. Hurley· 2 shared A. Kruse· 1 shared A. N. Dates· 1 shared A. Wellner· 1 shared A. Y. Shaw· 1 shared C. C. Liu· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

A. C. Kruse

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antibodies Expand the Scope of Angiotensin Receptor Pharmacology

M. A. Skiba, S. M. Sterling, S. Rawson, M. S. A. Gilman, H. Xu, G. R. Nemeth, J. D. Hurley, P. Shen, D. P. Staus, J. Kim, C. McMahon, M. K. Lehtinen, L. M. Wingler, A. C. Kruse

This study develops nanobody antagonists against the AT1R receptor, showing they can selectively bind and modulate the receptor with tunable ligand selectivity.

bioRxiv · Aug 23, 2023Pharmacology & Toxicology

Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled Receptors

A. N. Dates, D. T. D. Jones, J. S. Smith, M. A. Skiba, M. F. Rich, M. M. Burruss, A. C. Kruse, S. C. Blacklow

The paper profiles tethered agonist (TA) signaling in all 33 human aGPCRs using a platform across assays, revealing heterogeneous responses and aligning with AlphaFold2 predictions.

bioRxiv · Jul 14, 2022Biochemistry

Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation

J. E. Page, M. A. Skiba, T. Do, A. C. Kruse, S. Walker

The paper shows that ActH stabilizes metals in the LytH active site to activate amidase activity, revealing a general strategy for amidase activation.

bioRxiv · Jan 21, 2022Microbiology

An in silico method to assess antibody fragment polyreactivity

E. P. Harvey, J.-E. Shin, M. A. Skiba, G. R. Nemeth, J. D. Hurley, A. Wellner, A. Y. Shaw, V. G. Miranda, J. K. Min, C. C. Liu, D. S. Marks, A. Kruse

The paper develops a machine learning model to assess and reduce polyreactivity in nanobody sequences, achieving high accuracy and practical application through a web server.

bioRxiv · Jan 12, 2022 · PreprintPharmacology & Toxicology