The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation
M. Wachalska, C. Riepe, M. J. Slusarz, M. Graul, L. S. Borowski, W. Qiao, M. Foltynska, J. E. Carette, K. Bienkowska-Szewczyk, R. J. Szczesny, R. R. Kopito, A. D. Lipinska
This study identifies how BoHV-1 UL49.5 protein hijacks the C-degron pathway to promote TAP degradation via the CRL2 E3 ligase.
bioRxiv · Sep 27, 2023 · PreprintCell Biology