Author

R. R. Kopito

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Riepe· 2 shared K. K. Deol· 2 shared M. Wachalska· 2 shared P. A. DaRosa· 2 shared A. D. Lipinska· 1 shared A. J. Mathiowetz· 1 shared A. K. Amaya· 1 shared D. E. Leto· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

C. Riepe

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Small molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states

C. Riepe, M. Wachalska, K. K. Deol, A. K. Amaya, M. H. Porteus, J. Olzmann, R. R. Kopito

The paper identifies molecular machinery underlying CFTR-F508del ERAD and shows correctors stabilize RNF5-resistant folding states.

Molecular Biology of the Cell · Feb 1, 2024Peer-reviewedCell Biology

The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation

M. Wachalska, C. Riepe, M. J. Slusarz, M. Graul, L. S. Borowski, W. Qiao, M. Foltynska, J. E. Carette, K. Bienkowska-Szewczyk, R. J. Szczesny, R. R. Kopito, A. D. Lipinska

This study identifies how BoHV-1 UL49.5 protein hijacks the C-degron pathway to promote TAP degradation via the CRL2 E3 ligase.

bioRxiv · Sep 27, 2023 · PreprintCell Biology

RPL26/uL24 UFMylation is essential for ribosome-associated quality control at the endoplasmic reticulum

F. Scavone, S. C. Gumbin, P. A. DaRosa, R. R. Kopito

This paper shows that UFMylation of 60S ribosomal subunits at the ER is essential for proteasome access to ER-APs during ribosome-associated quality control.

bioRxiv · Mar 8, 2023Cell Biology

Parallel CRISPR-Cas9 screens reveal mechanisms of PLIN2 and lipid droplet regulation

M. A. Roberts, K. K. Deol, M. Lange, D. E. Leto, A. J. Mathiowetz, J. Stevenson, S. H. Hashemi, D. W. Morgens, E. Easter, K. Heydari, M. A. Nalls, M. C. Bassik, M. Kampmann, R. R. Kopito, F. Faghri, J. A. Olzmann

The paper uses CRISPR-Cas9 screens to identify genes regulating PLIN2 and lipid droplet abundance, revealing new mechanisms and creating a resource for lipid metabolism research.

bioRxiv · Aug 27, 2022 · PreprintCell Biology

Non canonical scaffold-type ligase complex mediates protein UFMylation

J. J. Peter, H. M. Magnussen, P. A. DaRosa, D. Millrine, S. P. Matthews, F. Lamoliatte, R. Sundaramoorthy, R. R. Kopito, Y. Kulathu

The paper identifies the minimal requirements for protein UFMylation and reveals the regulatory mechanism of an atypical scaffold-type E3 ligase complex.

bioRxiv · Jan 31, 2022 · PreprintBiochemistry