Single-cell atlas of tumor clonal evolution in liver cancer
L. Ma, L. Wang, C.-W. Chang, S. Heinrich, D. Dominguez, M. Forgues, J. Candia, M. O. Hernandez, M. Kelly, Y. Zhao, B. Tran, J. M. Hernandez, J. L. Davis, D. E. Kleiner, B. J. Wood, , X. W. Wang
This study constructs a single-cell atlas of liver cancer tumor clonality using machine learning and identifies osteopontin as a key driver of tumor evolution and immune reprogramming.
bioRxiv · Aug 18, 2020Cancer Biology