Y. Zhao

NINJ1 mediates hepatic ischemia-reperfusion injury

This study identifies NINJ1 as a mediator of hepatic ischemia-reperfusion injury, showing its role in cell death and inflammation, and suggests it as a therapeutic target.

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

This study identifies FRMD8 as a regulator of ER levels in ER-positive breast cancer, showing it confers tamoxifen resistance through dual mechanisms involving transcriptional and post-translational regulation of ER.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Linear-regression-based algorithms can succeed at identifying microbial functional groups despite the nonlinearity of ecological function

The paper evaluates regression-based methods for identifying microbial functional groups using synthetic data, finding that simpler linear methods can outperform complex ones.

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

An Omni-Mesoscope for multiscale high-throughput quantitative phase imaging of cellular dynamics and high-content molecular characterization

The paper introduces the Omni-Mesoscope, a cost-effective imaging platform that combines quantitative phase microscopy and multiplex fluorescence imaging to study cellular dynamics and molecular characteristics.

Robust data-driven segmentation of pulsatile cerebral vessels using functional magnetic resonance imaging

This study develops an automatic method to segment cerebral arteries and superior sagittal sinus from fMRI data, showing high reproducibility across age groups.

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

Conditioned immunological memory: implication for cognition of immune cells

This study demonstrates that immune cells can undergo classical conditioning, forming associations between hapten analogues and conjugates, leading to conditioned immunological memory and humoral immunosuppression.

Nitration of a ribosomal pentapeptide generates a noncanonical precursor for nonribosomal peptide synthesis

The paper shows ribosomal synthesis generates a noncanonical 3-nitrotyrosine building block used in nonribosomal peptide synthesis of rufomycin.

T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome

This study identifies EseB, a T3SS translocon protein, as a direct activator of the NLRC4/NAIP inflammasome, inducing pyroptosis in host cells through a conserved mechanism across T3SS-positive bacteria.

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

A standalone reverse dissimilatory sulfite reductase (rDsr) pathway enables sulfur oxidation under oxygen limitation

This study shows that the reverse dissimilatory sulfite reductase (rDsr) pathway can independently oxidize thiosulfate under low oxygen conditions, supporting its ecological role in marine sediments.

Multi-step engineered adeno-associated virus enables whole-brain mRNA delivery

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

Transcription network of SLC7A11 (xCT) in colon cancer provides clinical targets for metabolic regulation and cell proliferation

The paper analyzes RNA-seq data from CRC patients to identify SLC7A11's role in metabolic regulation and cell proliferation, linking it to clinical outcomes and therapeutic responses.

Developmental Control of Long-Distance mRNA Transport Involves m5C RNA Methylation and ALYREF Nuclear Export Factors

The paper investigates how m5C RNA methylation and ALY2/ALY4 nuclear export factors regulate mRNA transport during plant development, showing that this regulation changes with developmental stages.

New isolates refine the ecophysiology of the Roseobacter CHAB-I-5 lineage

The paper isolates two new CHAB-I-5 strains, analyzes their genomes, and proposes a new genus and species, highlighting ecological and physiological differences.

Skeleton-forming responses of reef-building corals under ocean acidification

This study examines how four coral species form skeletons under acidified conditions, revealing diverse strategies and damage patterns.

Improvement in Outcomes and Prevention of Multiple Organ Dysfunction Syndrome After Cardiac Arrest and Successful Cardiopulmonary Resuscitation by Systemic Administration of Bumetanide in Male Mice

This study shows that systemic bumetanide administration after cardiac arrest and CPR improves survival, reduces brain injury, and prevents multiple organ dysfunction in male mice, with LCN2/NGAL identified as a potential biomarker for early neuroprognostication.

Super homotypic targeting by exosome surface engineering

This paper enhances homotypic targeting by engineering exosome surfaces with lanthanides, significantly improving cell-exosome interactions and enabling new applications in diagnostics and therapy.

Ancient cyanobacterial proto-circadian clock adapted to short day-night cycles ~ 0.95 billion years ago

The paper reconstructs an ancient cyanobacterial circadian clock from ~0.95 billion years ago and shows it adapts to 18-h day-night cycles but lacks endogenous oscillation.

Molecular interplay between HURP and Kif18A in mitotic spindle regulation

This study investigates how HURP regulates Kif18A motility and microtubule dynamics during mitosis using single-molecule imaging and Cryo-EM.

Soft-lithographically defined template for arbitrarily patterned acoustic bioassembly

This paper introduces a soft-lithography-based acoustic bioassembly technique to create complex multicellular structures with functional liver tissue mimic capabilities.

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

This study shows that Piezo1 in intestinal L cells mechanically regulates GLP-1 production, affecting glucose tolerance and diabetes.

Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers

This paper identifies transcription-replication conflict as a vulnerability in ecDNA-containing cancers and demonstrates that CHK1 inhibition selectively kills these tumors.

3D live imaging and phenotyping of the subcellular cytotoxicity in cancer immunotherapy using event-triggered Bessel oblique plane microscopy

This study uses EBOPM to analyze subcellular events in CAR-T cells during immunotherapy, identifying key parameters correlated with cytotoxic function.

The origin and evolution of cultivated rice and genomic signatures of heterosis for yield traits in super-hybrid rice

This study investigates the evolutionary history of cultivated rice and identifies genomic signatures of heterosis in super-hybrid rice varieties.

GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.