Author

D. Dominguez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Biochemistry· 1 Bioengineering· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. B. Burge· 2 shared M. M. Aleman· 2 shared M. S. Alexis· 2 shared S. E. Harris· 2 shared A. Ingraldi· 1 shared A. J. Tabor· 1 shared A. Kovalenko· 1 shared A. M. House· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersEvolutionary Biology

C. B. Burge

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Author profile →

7 papers

Recent·Most cited

Understanding species-specific and conserved RNA-protein interactions in vivo and in vitro

S. E. Harris, M. S. Alexis, G. Giri, F. F. Cavazos, J. Murn, M. M. Aleman, C. B. Burge, D. Dominguez

The paper examines interspecies differences in RNA-protein interactions using the neuronal RNA binding protein UNK, finding conserved binding patterns and species-specific sequence determinants.

bioRxiv · Jan 29, 2024 · PreprintEvolutionary Biology

Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.

L. Caeiro, Y. Nakata, R. L. Borges, L. Garcia-Martinez, C. Banuelos, S. Stransky, H. L. Chan, J. Brabson, D. Dominguez, Y. Zhang, P. W. Lewis, S. A. Benitah, L. Cimmino, D. Bilbao, S. Sidoli, , L. Morey

This study shows that H3K36M mutations in HNSCC create a therapeutic window by altering H3K27me3 levels, making tumors sensitive to PARP1/2 inhibitors or their combination with H3K27me3-upregulating agents.

bioRxiv · Nov 6, 2023Cancer Biology

Visualization of liquid-liquid phase transitions using a tiny G-quadruplex binding protein

B. R. Sahoo, X. Deng, E. L. Wong, N. Clark, H. Yang, V. Subramanian, B. B. Guzman, S. E. Harris, B. Dehury, E. Miyashita, J. D. Hoff, V. Kocman, H. Saito, D. Dominguez, J. Plavec, , A. Kovalenko

The paper identifies SERF2 as a protein involved in stress granule formation and characterizes its interactions with G-quadruplex RNA structures to study liquid-liquid phase transitions.

bioRxiv · Oct 9, 2023Cell Biology

Quantitative Profiling of Adaptation to Cyclin E Overproduction

J. C. Limas, A. N. Littlejohn, A. M. House, K. M. Kedziora, B. L. Mouery, B. Ma, D. Fleifel, A. Walens, M. M. Aleman, D. Dominguez, J. G. Cook

This study examines how mammalian cells adapt to chronic cyclin E overproduction, revealing that adaptation involves downregulation of G1-regulated genes and partial resistance to replication stress.

bioRxiv · Jul 26, 2021Cell Biology

Improved Wound Closure Rates and Mechanical Properties Resembling Native Skin in Murine Diabetic Wounds Treated with a Tropoelastin and Collagen Wound Healing Device

R. S. Kellar, R. Diller, A. J. Tabor, D. Dominguez, R. Audet, T. Bardsley, A. Talbert, N. Cruz, A. Ingraldi, B. Ensley

This study evaluates a tropoelastin and collagen scaffold for diabetic wound healing in mice, showing improved closure rates and tissue properties compared to a commercial matrix.

bioRxiv · Oct 1, 2020 · PreprintBioengineering

Single-cell atlas of tumor clonal evolution in liver cancer

L. Ma, L. Wang, C.-W. Chang, S. Heinrich, D. Dominguez, M. Forgues, J. Candia, M. O. Hernandez, M. Kelly, Y. Zhao, B. Tran, J. M. Hernandez, J. L. Davis, D. E. Kleiner, B. J. Wood, , X. W. Wang

This study constructs a single-cell atlas of liver cancer tumor clonality using machine learning and identifies osteopontin as a key driver of tumor evolution and immune reprogramming.

bioRxiv · Aug 18, 2020Cancer Biology

Sequence, Structure and Context Preferences of Human RNA Binding Proteins

D. Dominguez, P. Freese, M. S. Alexis, A. Su, M. Hochman, T. Palden, C. Bazile, N. J. Lambert, E. L. Van Nostrand, G. A. Pratt, G. W. Yeo, B. Graveley, C. B. Burge

The paper presents affinity landscapes of 78 human RNA binding proteins using deep sequencing to determine sequence, structure, and context preferences, revealing patterns of low motif diversity and contextual feature preferences.

bioRxiv · Oct 12, 2017Biochemistry