A2E induces the transactivation of RARs, PPARs and RXRs and its effects are counteracted by norbixin in retinal pigment epithelium cells in vitro
V. Fontaine, M. Fournie, E. Monteiro, T. Boumedine, C. Balducci, L. Guibout, M. Latil, P. J. Dilda, J. A. Sahel, S. Veillet, R. Lafont, S. Camelo
This study shows A2E activates RARs, PPARs, and RXRs in RPE cells, and norbixin counteracts these effects, offering potential for AMD treatment.
bioRxiv · Mar 30, 2020 · PreprintCell Biology