An Innovative Non-Hormonal Strategy Targeting Redox Active Metals to Down-Regulate Estrogen-, Progesterone-, Androgen- and Prolactin-Receptors in Breast Cancer
F. Shehadeh-Tout, H. H. Milioli, S. Roslan, P. J. Jansson, M. Dharmasivam, D. Graham, R. Anderson, T. Wijesinghe, M. G. Azad, D. R. Richardson, Z. Kovacevic
This paper investigates the effects of redox-active compounds Dp44mT and DpC on hormone receptors and resistance pathways in breast cancer, showing they suppress receptor expression and signaling through metal ion binding.
bioRxiv · Feb 2, 2023 · PreprintCancer Biology