R. Anderson

Explainable machine learning reveals an RBP regulatory logic of exon skipping

The paper uses explainable machine learning to uncover RBP binding patterns that predict exon skipping and reveals biologically interpretable regulatory logic.

Phylogenomics of novel clones of Aeromonas veronii recovered from a freshwater lake reveals unique biosynthetic gene clusters

This study identifies novel biosynthetic gene clusters in Aeromonas veronii isolates from a freshwater lake, revealing genetic diversity and potential for unique secondary metabolite production.

Hyperactive 20S Proteasome Enhances Proteostasis and ERAD in C. elegans via degradation of Intrinsically Disordered Proteins.

This study shows that a hyperactive 20S proteasome in C. elegans improves degradation of misfolded proteins, reduces oxidative damage, and extends lifespan without relying on known proteostasis pathways.

Adaptive gene loss in the common bean pan-genome during range expansion and domestication

This study identifies adaptive gene loss in common bean populations during range expansion and domestication, showing gene loss as a key adaptive trait.

Timing the Evolution of Phosphorus-Cycling 1 Enzymes Through Geological Time

The paper reconstructs the evolutionary timeline of phosphorus-cycling enzymes and links their development to changes in phosphate concentrations and geological events.

Antibodies generated in vitro and in vivo elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine

This study develops a thermostable ADDomer-based nanoparticle vaccine that neutralizes SARS-CoV-2 and cross-reacts with VOCs, demonstrating its potential for nasal administration.

An Innovative Non-Hormonal Strategy Targeting Redox Active Metals to Down-Regulate Estrogen-, Progesterone-, Androgen- and Prolactin-Receptors in Breast Cancer

This paper investigates the effects of redox-active compounds Dp44mT and DpC on hormone receptors and resistance pathways in breast cancer, showing they suppress receptor expression and signaling through metal ion binding.

A microRNA expression signature in infant t(4;11) MLL-AF4+ BCP-ALL uncovers novel therapeutic targets

This study identifies three microRNAs downregulated in MLL-AF4+ BCP-ALL and shows that targeting their downstream genes with existing drugs reduces leukemia burden.

Cellular production of a de novo membrane cytochrome

The paper designs and produces a synthetic diheme membrane cytochrome in bacteria that mimics natural electron transport features without natural sequence homology.

Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice

AdipoRon, an adiponectin receptor agonist, improves skeletal muscle function in aged mice by enhancing mitochondrial activity and metabolism, with effects observed in both mice and nonhuman primates.

Topological digestion drives time-varying rheology of entangled DNA fluids

This study investigates DNA-based complex fluids that undergo enzymatic topological changes, showing time-dependent rheological behavior controlled by restriction endonuclease reactions.

High-resolution genomic comparisons within Salmonella enterica serotypes derived from beef feedlot cattle: parsing the roles of cattle source, pen, animal, sample type and production period

This study uses genomic analysis to examine Salmonella subpopulation dynamics in cattle, finding that clonal expansion is mainly influenced by pen and cattle origin, not sampling time or type.

Topological Tuning of DNA Mobility in Entangled Solutions of Supercoiled Plasmids

This study combines simulations and experiments to show that supercoiling increases DNA plasmid size and mobility in entangled solutions, challenging existing assumptions about DNA behavior.

Evolution of dynamical networks enhances catalysis in a designer enzyme

This study shows that directed evolution of a designer enzyme introduces dynamical changes that increase activation heat capacity and nonlinearity in temperature dependence through correlated dynamical networks.

Validation and Application of a Bench Top Cell Sorter in a BSL-3 Containment Setting

The paper validates a benchtop cell sorter for safe use in BSL-3 settings, demonstrating its utility for infectious disease research.

An oomycete RXLR effector triggers antagonistic plant hormone crosstalk to suppress host immunity

The paper shows that the oomycete effector HaRxL10 targets JAZ3 to inhibit SA signaling and suppress plant immunity through JA-SA crosstalk.

Length-independent telomere damage drives cardiomyocyte senescence

This study shows that telomere damage independent of length causes cardiomyocyte senescence, leading to cardiac dysfunction, and that clearing senescent cells improves cardiac health.