BiochemistrybioRxiv
Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays
J. G. Van Vranken, J. Li, J. Mintseris…·D. K. Schweppe
This study uses proteome-wide thermal shift assays to analyze over a million thermal stability measurements from 96 compounds in cells and 70 in lysates, revealing target engagement and off-target effects.
DOI 10.7554/elife.95595