Author

D. K. Schweppe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 5 Approach:experimental assay· 4 Research Focus:benchmarking· 3 Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

C. D. McGann· 2 shared S. P. Gygi· 2 shared B. K. Erickson· 1 shared C. Lin· 1 shared C. M. Sniezek· 1 shared D. A. Faivre· 1 shared D. Bailey· 1 shared D. M. Shechner· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiochemistry

C. D. McGann

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Author profile →

6 papers

Recent·Most cited

Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays

J. G. Van Vranken, J. Li, J. Mintseris, T.-Y. Wei, C. M. Sniezek, M. Gadzuk-Shea, S. P. Gygi, D. K. Schweppe

This study uses proteome-wide thermal shift assays to analyze over a million thermal stability measurements from 96 compounds in cells and 70 in lysates, revealing target engagement and off-target effects.

bioRxiv · Jan 26, 2024Biochemistry

High-Throughput Identification of Calcium Regulated Proteins Across Diverse Proteomes

T. M. Locke, R. Fields, H. Gizinski, G. M. Otto, D. M. Shechner, M. D. Berg, J. Villen, Y. Sancak, D. K. Schweppe

The paper identifies 2884 calcium-regulated proteins across human, mouse, and yeast proteomes using thermostability assays and reveals novel calcium engagement in metabolic enzymes and the spliceosome.

bioRxiv · Jan 18, 2024Cell Biology

Comparing peptide identifications by FAIMS versus quadrupole gas-phase fractionation

D. A. Faivre, C. D. McGann, G. E. Merrihew, D. K. Schweppe, M. J. MacCoss

This study compares FAIMS and quadrupole gas-phase fractionation in peptide identification, finding that FAIMS improves results mainly by reducing co-isolation of precursor ions and chimeric spectra.

bioRxiv · Sep 1, 2023 · PreprintBiochemistry

Real-time spectral library matching for sample multiplexed quantitative proteomics.

C. D. McGann, W. D. Barshop, J. Canterbury, C. Lin, W. Gabriel, M. Wilhelm, G. McAlister, D. K. Schweppe

This paper introduces a real-time library searching workflow to improve quantitation in sample multiplexed proteomics by enabling intelligent scan triggering and peak selection.

bioRxiv · Feb 8, 2023Cell Biology

Redox-dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery

E. Skeens, M. M. Gadzuk-Shea, D. Shah, V. Bhandari, D. K. Schweppe, R. B. Berlow, G. P. Lisi

This study investigates how redox conditions affect the structure and function of MIF, identifying redox-sensitive sites that modulate its interaction with CD74.

bioRxiv · Sep 1, 2021Biophysics

Full-featured, real-time database searching platform enables fast and accurate multiplexed quantitative proteomics.

D. K. Schweppe, J. K. Eng, D. Bailey, R. Rad, Q. Yu, J. Navarrete-Perea, E. L. Huttlin, B. K. Erickson, J. A. Paulo, S. P. Gygi

The paper introduces a real-time database search platform, Orbiter, that improves the efficiency and accuracy of multiplexed quantitative proteomics by reducing data acquisition time and increasing protein quantification.

bioRxiv · Jun 12, 2019Cell Biology