IRF5 promotes intestinal inflammation by guiding monocyte differentiation towards a pathogenic CD11c+ macrophage phenotype
A. L. Corbin, M. Gomez-Vazquez, T. E. Khoyratty, D. L. Berthold, H. Almuttaqi, M. Attar, I. C. Arnold, F. M. Powrie, S. N. Sansom, I. A. Udalova
This study shows IRF5 promotes pathogenic CD11c+ macrophage differentiation from monocytes in the gut, worsening inflammation during colitis.
bioRxiv · Apr 7, 2019 · PreprintImmunology