Author

I. A. Udalova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

A. L. Corbin· 2 shared H. Almuttaqi· 2 shared Z. Ai· 2 shared A. Clarke· 1 shared A. Cross· 1 shared A. E. Armitage· 1 shared A. E. Preston· 1 shared B. Galy· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

A. L. Corbin

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Author profile →

3 papers

Recent·Most cited

Plasma iron controls neutrophil production and function

J. N. Frost, S. K. Wideman, A. E. Preston, M. R. Teh, Z. Ai, L. Wang, A. Cross, N. White, Y. Yazicioglu, M. Bonadonna, A. Clarke, A. E. Armitage, B. Galy, I. A. Udalova, H. Drakesmith

The paper shows hypoferremia reduces neutrophil production and alters their function, while increasing NETosis, and suggests targeting hepcidin could modulate innate immunity.

bioRxiv · Mar 17, 2022Immunology

PYK2 controls intestinal inflammation via activation of IRF5 in macrophages

G. Ryzhakov, H. Almuttaqi, A. L. Corbin, T. Khoyratty, D. Berthold, S. Bullers, H. L. Eames, Z. Ai, S. Bonham, R. Fischer, L. Jostins-Dean, S. P. L. Travis, B. M. Kessler, I. A. Udalova

This study identifies PYK2 as a key regulator of intestinal inflammation by activating IRF5 in macrophages, showing reduced inflammation in colitis models and human ulcerative colitis biopsies.

bioRxiv · May 24, 2020 · PreprintImmunology

IRF5 promotes intestinal inflammation by guiding monocyte differentiation towards a pathogenic CD11c+ macrophage phenotype

A. L. Corbin, M. Gomez-Vazquez, T. E. Khoyratty, D. L. Berthold, H. Almuttaqi, M. Attar, I. C. Arnold, F. M. Powrie, S. N. Sansom, I. A. Udalova

This study shows IRF5 promotes pathogenic CD11c+ macrophage differentiation from monocytes in the gut, worsening inflammation during colitis.

bioRxiv · Apr 7, 2019 · PreprintImmunology