Rifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion
C. Genestet, E. Hodille, A. Barbry, J.-L. Berland, J. Hoffmann, E. Westeel, F. Bastian, M. Guichardant, S. Venner, G. Lina, C. Ginevra, F. Ader, S. Goutelle, O. Dumitrescu, on behalf of the Lyon TB study group
The paper analyzes genetic diversity in Mycobacterium tuberculosis isolates from TB patients with delayed culture conversion, revealing drug-tolerant sub-populations and their potential role in treatment failure.
bioRxiv · May 22, 2020 · PreprintMicrobiology