Adaptive evolution of Topoisomerase II triggers reproductive isolation in Drosophila
Cara L. Brand, Nicholas Brown, Anirban Dasgupta, Michael Buszczak, M. H. Levine
This study identifies Topoisomerase II divergence as a cause of reproductive isolation between Drosophila species due to its role in resolving DNA satellite-induced topological stress.
bioRxiv · Feb 21, 2026 · PreprintEvolutionary Biology