Pre-existing immunity modulates responses to mRNA boosters
T. Dangi, S. Sanchez, M. H. Lew, L. Visvabharathy, J. M. Richner, I. Koralnik, P. Penaloza-MacMaster
The paper shows pre-existing immunity affects the effectiveness of mRNA vaccine boosters, with lower pre-existing antibodies leading to greater post-booster increases and updated vaccines being more effective in certain serostatus groups.
bioRxiv · Jun 27, 2022Immunology