Author

M. H. Vaarala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Ahtikoski· 2 shared A. Manninen· 2 shared G.-H. Wei· 2 shared Q. Zhang· 2 shared R. Devarajan· 2 shared T. Wenta· 2 shared A. Schmidt· 1 shared B. Luo· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

A. Ahtikoski

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2 papers

Recent·Most cited

TEAD1 regulates ITGA1 and ITGA2 to control prostate cancer progression

S. P. Cruz, Q. Zhang, R. Devarajan, C. Paia, B. Luo, K. Zhang, J. Xia, A. Ahtikoski, M. H. Vaarala, T. Wenta, G.-H. Wei, A. Manninen

This study identifies TEAD1 as a regulator of ITGA1 and ITGA2 in prostate cancer, showing their loss promotes tumor progression via TGFβ1-driven EMT.

bioRxiv · Apr 12, 2023Cancer Biology

Disassembly of hemidesmosomes promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin into focal adhesions

T. Wenta, A. Schmidt, Q. Zhang, R. Devarajan, P. Singh, X. Yang, A. Ahtikoski, M. H. Vaarala, G.-H. Wei, A. Manninen

This study shows that loss of PTEN and hemidesmosomes in prostate cancer promotes tumorigenesis by activating EGFR/PI3K/Akt and FAK/Src pathways through plectin mislocalization.

bioRxiv · Nov 8, 2021Cancer Biology