The metalloproteinase inhibitor Prinomastat reduces AML growth,prevents stem cell loss and improves chemotherapy effectiveness
C. Pirillo, M. Haltalli, S. Gonzalez Anton, V. Tini, I. Kong, E. Hawkins, B. Falini, A. Marra, D. Duarte, C. Lo Celso
This study shows that prinomastat, an MMP inhibitor, reduces AML growth, prevents stem cell loss, and enhances chemotherapy effectiveness in a mouse model.
bioRxiv · Dec 1, 2020 · PreprintCancer Biology