M. Hoehne

Mechanical forces at the kidney filtration barrier govern spatial orientation of podocyte processes on capillaries

This study shows that podocyte processes align along the capillary axis to balance mechanical strain during kidney filtration.

Three-dimensional Super-resolved Imaging of Paraffin-embedded Kidney Samples

This paper develops protocols for three-dimensional STED and confocal imaging of FFPE kidney tissue, achieving similar staining and image quality as previous methods.

Organ protection by caloric restriction depends on activation of the de novo NAD+ synthesis pathway

This study identifies KYNU-dependent de novo NAD+ biosynthesis as a mechanism by which caloric restriction protects against acute kidney injury in mice and humans.

Deep learning-based segmentation and quantification of podocyte foot process morphology

This paper develops a deep learning method to segment and quantify podocyte foot process morphology in kidney tissue, confirming morphological changes in disease states.

Par3A and Par3B orchestrate podocyte architecture by regulating RhoA levels

This study shows that Par3A and Par3B regulate RhoA levels and podocyte architecture through interactions with Synaptopodin and CD2AP in mouse and Drosophila models.