B. Denholm

Evidence for the independent evolution of a rectal complex within the beetle superfamily Scarabaeoidea

The paper provides evidence for the independent evolution of rectal complexes in the Scarabaeoidea beetle superfamily through comparative anatomical observations.

Piezo buffers mechanical stress via modulation of intracellular Ca2+ handling in the Drosophila heart

This study shows that Piezo channels in Drosophila hearts modulate intracellular Ca2+ handling to buffer mechanical stress and prevent arrhythmias.

Piezo activity levels need to be tightly regulated to maintain normal morphology and function in pericardial nephrocytes

Drosophila Filamin exhibits a mechano-protective role during nephrocyte injury via induction of hypertrophic growth

This study identifies Cheerio (dFilamin) as a mechano-protective factor in Drosophila nephrocytes, inducing hypertrophy to preserve filtration function during injury.

A Unique Renal Architecture in Tribolium castaneum Informs the Evolutionary Origins of Systemic Osmoregulation in Beetles

This paper identifies a unique renal architecture in beetles that uses diuretic hormones to regulate osmotic balance, revealing evolutionary adaptations for water stress resistance.

Par3A and Par3B orchestrate podocyte architecture by regulating RhoA levels

This study shows that Par3A and Par3B regulate RhoA levels and podocyte architecture through interactions with Synaptopodin and CD2AP in mouse and Drosophila models.