Physiological and Metabolic Features of Mice with CRISPR/Cas9-Mediated Loss-of-Function in Growth Hormone-Releasing Hormone
F. Zhang, S. Y. Liou, A. K. Challa, M. P. Fitch, M. Icyuz
This study shows that CRISPR/Cas9-generated GHRH-/- mice have reduced body weight, improved insulin sensitivity, and altered metabolism, consistent with previous findings on growth hormone deficiency.
bioRxiv · Feb 7, 2020Physiology