Author

M. J. Chalkley

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Biophysics· 1

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

D. R. Southworth· 1 shared E. Tse· 1 shared G. E. Merz· 1 shared J. Lee· 1 shared N. A. Paras· 1 shared S. B. Prusiner· 1 shared S. K. Tan· 1 shared W. F. DeGrado· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBiophysics

D. R. Southworth

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1 paper

Recent·Most cited

Stacked binding of a small molecule PET tracer to Alzheimer's tau paired helical filaments

G. E. Merz, M. J. Chalkley, S. K. Tan, E. Tse, J. Lee, S. B. Prusiner, N. A. Paras, W. F. DeGrado, D. R. Southworth

The paper determines the cryo-EM structure of GTP-1 bound to Alzheimer's tau filaments, revealing a stacked binding arrangement and favorable pi-pi interactions.

bioRxiv · Sep 30, 2022 · PreprintBiophysics