Author

S. B. Prusiner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Lee· 2 shared N. A. Paras· 2 shared A. J. Butte· 1 shared A. Laeremans· 1 shared D. R. Southworth· 1 shared D. R. Wong· 1 shared E. Tse· 1 shared G. E. Merz· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiophysics

J. Lee

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2 papers

Recent·Most cited

Stacked binding of a small molecule PET tracer to Alzheimer's tau paired helical filaments

G. E. Merz, M. J. Chalkley, S. K. Tan, E. Tse, J. Lee, S. B. Prusiner, N. A. Paras, W. F. DeGrado, D. R. Southworth

The paper determines the cryo-EM structure of GTP-1 bound to Alzheimer's tau filaments, revealing a stacked binding arrangement and favorable pi-pi interactions.

bioRxiv · Sep 30, 2022 · PreprintBiophysics

Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics

D. R. Wong, J. Conrad, N. Johnson, J. I. Ayers, A. Laeremans, J. C. Lee, J. Lee, S. B. Prusiner, S. Bandyopadhyay, A. J. Butte, N. A. Paras, M. J. Keiser

This paper introduces a deep learning method to improve high-content screening for Alzheimer's disease therapeutics by generating predicted fluorescent signals from alternative markers.

bioRxiv · Jan 8, 2021Pharmacology & Toxicology