Author

S. K. Tan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

W. DeGrado· 2 shared A. Multani· 1 shared A. Yu· 1 shared C. Condello· 1 shared D. A. Relman· 1 shared D. R. Southworth· 1 shared E. Tse· 1 shared F. Strouts· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiophysics

W. DeGrado

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

De novo Design of Peptides that Bind Specific Conformers of α-Synuclein

H. Wallace, H. Yang, S. K. Tan, H. Pan, R. Yang, J. Xu, H. Jo, C. Condello, N. Polizzi, W. DeGrado

This paper introduces a computational method to design peptides that bind specific conformers of α-synuclein fibrils, resulting in a peptide that slows amyloid formation and shows high specificity.

bioRxiv · Nov 14, 2023 · PreprintBiophysics

Stacked binding of a small molecule PET tracer to Alzheimer's tau paired helical filaments

G. E. Merz, M. J. Chalkley, S. K. Tan, E. Tse, J. Lee, S. B. Prusiner, N. A. Paras, W. F. DeGrado, D. R. Southworth

The paper determines the cryo-EM structure of GTP-1 bound to Alzheimer's tau filaments, revealing a stacked binding arrangement and favorable pi-pi interactions.

bioRxiv · Sep 30, 2022 · PreprintBiophysics

Elucidation of the molecular interactions that enable stable assembly and structural diversity in multicomponent immune receptors

L.-K. Fong, M. J. Chalkely, S. K. Tan, M. Grabe, W. DeGrado

The paper identifies a carboxyl-carboxylate clamp motif in transmembrane domains of immune receptors that enables stable assembly and structural diversity through dynamic interactions.

bioRxiv · Dec 22, 2020Biophysics

Combined use of metagenomic sequencing and host response profiling for the diagnosis of suspected sepsis.

H. K. Cheng, S. K. Tan, T. E. Sweeney, P. Jeganathan, T. Briese, V. Khadka, F. Strouts, S. Thair, S. Dalai, M. Hitchcock, A. Multani, J. Aronson, T. Andermann, A. Yu, S. Yang, , D. A. Relman

This study combines metagenomic sequencing and host response profiling to improve sepsis diagnosis by detecting pathogens and guiding clinical decisions.

bioRxiv · Dec 9, 2019 · PreprintMicrobiology