Connexin 43 Regulates Intercellular Mitochondrial Transfer from Human Mesenchymal Stromal Cells to Chondrocytes
R. M. Irwin, M. A. Thomas, M. J. Fahey, M. D. Mayan, J. W. Smyth, M. L. Delco
This study shows that Cx43 and its isoform GJA1-20k facilitate mitochondrial transfer from mesenchymal stromal cells to chondrocytes, particularly under oxidative stress, suggesting potential therapeutic applications for osteoarthritis.
bioRxiv · Mar 18, 2024Bioengineering