Author

J. W. Smyth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

R. G. Gourdie· 2 shared C. Chuong· 1 shared C. M. Phillips· 1 shared D. R. King· 1 shared E. Nurmemmedov· 1 shared G. A. Blair· 1 shared G. S. Hoeker· 1 shared J. Dahlka· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

R. G. Gourdie

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Connexin 43 Regulates Intercellular Mitochondrial Transfer from Human Mesenchymal Stromal Cells to Chondrocytes

R. M. Irwin, M. A. Thomas, M. J. Fahey, M. D. Mayan, J. W. Smyth, M. L. Delco

This study shows that Cx43 and its isoform GJA1-20k facilitate mitochondrial transfer from mesenchymal stromal cells to chondrocytes, particularly under oxidative stress, suggesting potential therapeutic applications for osteoarthritis.

bioRxiv · Mar 18, 2024Bioengineering

Increased interaction between connexin43 and microtubules is critical for glioblastoma stem-like cell maintenance and tumorigenicity.

J. W. Smyth, S. Guo, L. O'Rourke, S. Deaver, J. Dahlka, E. Nurmemmedov, Z. Sheng, R. G. Gourdie, S. Lamouille

This study identifies a novel peptide, JM2, that disrupts Cx43-microtubule interaction in GBM stem-like cells, reducing their survival and tumorigenicity.

bioRxiv · Jan 26, 2024 · PreprintCancer Biology

Acute adenoviral infection elicits an arrhythmogenic substrate prior to myocarditis

R. L. Padget, M. J. Zeitz, G. A. Blair, X. Wu, M. D. North, G. S. Hoeker, K. E. Stanley, C. M. Phillips, D. R. King, R. G. Gourdie, M. T. Tanenbaum, G. S. Hoeker, S. A. Swanger, S. Poelzing, J. W. Smyth

This study shows adenoviral infection causes arrhythmogenic changes in the heart before significant immune response, through gap junction and ion channel dysfunction.

bioRxiv · Nov 29, 2022Pathology

Adenovirus transduction to express human ACE2 causes obesity-specific morbidity in mice, impeding studies on the effect of host nutritional status on SARS-CoV-2 pathogenesis.

P. Rai, C. Chuong, T. LeRoith, J. W. Smyth, N. K. Duggal, J. Weger-Lucarelli, J. Panov, M. Levi, K. K. Hall

This study shows that adenovirus-mediated ACE2 expression in mice causes obesity-specific morbidity, complicating research on SARS-CoV-2 pathogenesis in different nutritional states.

bioRxiv · May 26, 2021Pathology