Post-vaccine epidemiology of serotype 3 pneumococci identifies transformation inhibition through prophage-driven alteration of a non-coding RNA
M. J. Kwun, A. V. Ion, H.-C. Cheng, J. C. D'Aeth, S. Dougan, M. R. Oggioni, D. A. Goulding, S. D. Bentley, N. J. Croucher
The paper identifies prophage-driven modification of a non-coding RNA that inhibits transformation in pneumococci, explaining the persistence of serotype 3 despite vaccination.
bioRxiv · Sep 21, 2022Microbiology