Author

N. J. Croucher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 4

Signature Assays, Organisms & Methods

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Approach:statistical model· 7 Assay:whole-genome sequencing· 5 Organism:human· 4 Organism:bacteria (other)· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:clustering· 2 Research Focus:gene regulatory network inference· 2 Approach:Bayesian inference· 1

Frequent Co-Authors

S. D. Bentley· 4 shared A. V. Ion· 2 shared C. Fraser· 2 shared J. Corander· 2 shared M. J. Kwun· 2 shared M. Lipsitch· 2 shared M. R. Oggioni· 2 shared W. P. Hanage· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersMicrobiology

S. D. Bentley

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Author profile →

9 papers

Recent·Most cited

Post-vaccine epidemiology of serotype 3 pneumococci identifies transformation inhibition through prophage-driven alteration of a non-coding RNA

M. J. Kwun, A. V. Ion, H.-C. Cheng, J. C. D'Aeth, S. Dougan, M. R. Oggioni, D. A. Goulding, S. D. Bentley, N. J. Croucher

The paper identifies prophage-driven modification of a non-coding RNA that inhibits transformation in pneumococci, explaining the persistence of serotype 3 despite vaccination.

bioRxiv · Sep 21, 2022Microbiology

Diverse regulatory pathways modulate bet hedging of competence induction in epigenetically-differentiated phase variants of Streptococcus pneumoniae

M. J. Kwun, A. V. Ion, M. R. Oggioni, S. D. Bentley, N. J. Croucher

The paper identifies diverse regulatory pathways affecting transformation efficiency in Streptococcus pneumoniae phase variants through differential gene expression and chromosomal island activity.

bioRxiv · Mar 7, 2022 · PreprintMicrobiology

Diverse Genetic Determinants of Nitrofurantoin Resistance in UK Escherichia coli

Y. Wan, E. Mills, R. C. Y. Leung, A. Vieira, E. Jauneikaite, X. Zhi, N. J. Croucher, N. Woodford, M. J. Ellington, S. Sriskandan

This study identifies genetic factors causing nitrofurantoin resistance in UK E. coli, finding mutations and insertion sequences in nfsA and nfsB as major contributors.

Microbial Genomics · Dec 24, 2021Peer-reviewedMicrobiology

Analysing pneumococcal invasiveness using Bayesian models of pathogen progression rates

A. Lochen, J. E. Truscott, N. J. Croucher

This paper develops Bayesian models to estimate pneumococcal invasiveness from surveillance data, showing they provide accurate and informative estimates of progression rates from carriage to disease.

bioRxiv · Sep 1, 2021Microbiology

Epidemiological dynamics of bacteriocin competition and antibiotic resistance

S. Lehtinen, N. J. Croucher, F. Blanquart, C. Fraser

This study examines bacteriocin dynamics and their link to antibiotic resistance in epidemiological models, finding that diversity can be maintained through competition-colonisation trade-offs rather than rock-paper-scissors dynamics.

bioRxiv · Oct 23, 2020Evolutionary Biology

Negative frequency-dependent selection and asymmetrical transformation stabilise multi-strain bacterial population structures

G. L. Harrow, J. A. Lees, W. P. Hanage, M. Lipsitch, J. Corander, C. Colijn, N. J. Croucher

The paper tests whether negative frequency-dependent selection and asymmetrical recombination can explain the stability of multi-strain bacterial populations using simulations and genomic data.

bioRxiv · Jun 5, 2020Evolutionary Biology

Horizontal gene transfer rate is not the primary determinant of observed antibiotic resistance frequencies in Streptococcus pneumoniae

S. J. Lehtinen, C. Chewapreecha, W. P. Hanage, M. J. Lipsitch, N. J. Croucher, S. D. Bentley, P. Turner, C. Fraser, R. J. Mostowy

The study examines antibiotic resistance frequencies in Streptococcus pneumoniae and finds that horizontal gene transfer rates are not the main factor influencing these frequencies.

bioRxiv · Jun 11, 2019Evolutionary Biology

Population genomics of pneumococcal carriage in Massachusetts children following PCV-13 introduction

P. Mitchell, T. Azarian, N. J. Croucher, A. Callendrello, C. M. Thompson, S. I. Pelton, M. Lipsitch, W. Hanage

This study examines changes in pneumococcal carriage diversity and lineage distribution in Massachusetts children after PCV-13 introduction, finding increased diversity post-vaccination followed by a return to pre-vaccination levels.

Microbial Genomics · Feb 1, 2019Peer-reviewedEvolutionary Biology

PANINI: Pangenome Neighbor Identification for Bacterial Populations

K. Abudahab, J. M. Prada, Z. Yang, S. D. Bentley, N. J. Croucher, J. Corander, D. M. Aanensen

PANINI identifies bacterial population neighbours using machine learning, integrating core and accessory genome data with metadata for epidemiological analysis.

bioRxiv · Aug 21, 2017Microbiology