Author

H.-C. Cheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. V. Ion· 1 shared A.-G. Wang· 1 shared C.-C. Chien· 1 shared C.-L. Wang· 1 shared C.-Y. Lin· 1 shared D. A. Goulding· 1 shared G. V. Pusapati· 1 shared G.-S. Chiu· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperMicrobiology

A. V. Ion

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2

R.-H. Wang, P.-R. Chen, Y.-T. Chen, Y.-C. Chen, Y.-H. Chu, C.-C. Chien, P.-C. Chien, S.-Y. Lo, Z.-L. Wang, M.-C. Tsou, S.-Y. Chen, G.-S. Chiu, W.-L. Chen, Y.-H. Wu, L. Wang, , K.-T. Lin

This study shows hydrogen sulfide destabilizes PKM2 tetramer through sulfhydration at cysteine 326, rewiring glucose metabolism and inhibiting tumor growth.

bioRxiv · Sep 2, 2023Cancer Biology

The efficient induction of human retinal ganglion-like cells provides a platform for studying optic neuropathies

R. H.-C. Liou, S.-W. Chen, H.-C. Cheng, P.-C. Wu, Y.-F. Chang, A.-G. Wang, M.-J. Fann, Y.-H. Wong

This paper develops a method to efficiently generate human retinal ganglion-like cells from iPSCs and uses them to study the effects of ethambutol on RGC degeneration.

bioRxiv · Jul 1, 2023Cell Biology

Post-vaccine epidemiology of serotype 3 pneumococci identifies transformation inhibition through prophage-driven alteration of a non-coding RNA

M. J. Kwun, A. V. Ion, H.-C. Cheng, J. C. D'Aeth, S. Dougan, M. R. Oggioni, D. A. Goulding, S. D. Bentley, N. J. Croucher

The paper identifies prophage-driven modification of a non-coding RNA that inhibits transformation in pneumococci, explaining the persistence of serotype 3 despite vaccination.

bioRxiv · Sep 21, 2022Microbiology

Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling

S.-R. Hong, C.-L. Wang, Y.-S. Huang, Y.-C. Chang, Y.-C. Chang, G. V. Pusapati, C.-Y. Lin, N. Hsu, H.-C. Cheng, Y.-C. Chiang, W.-E. Huang, N. C. Shaner, R. Rohatgi, T. Inoue, Y.-C. Lin

The paper develops a method to rapidly deplete tubulin glutamylation in primary cilia, revealing its role in intraflagellar transport and Hedgehog signaling without affecting other PTMs.

bioRxiv · Mar 15, 2018Cell Biology