Author

M. J. Slepian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Approach:statistical model· 1

Frequent Co-Authors

Y. Roka-Moiia· 3 shared D. Bluestein· 2 shared J. E. Italiano· 2 shared J. Sheriff· 2 shared A. Sweedo· 1 shared E. Cleveland· 1 shared F. Teran Arce· 1 shared J. G. Purdy· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

Y. Roka-Moiia

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Shear Stress Promotes Remodeling of Platelet Glycosylation via Upregulation of Platelet Glycosidase Activity: The Ulterior Cause of MCS-Related Thrombocytopenia?

Y. Roka-Moiia, S. Lewis, E. Cleveland, J. E. Italiano, M. J. Slepian

This study shows shear stress increases platelet glycosidase activity, leading to glycosylation remodeling, platelet count decline, and microvesiculation in MCS patients.

bioRxiv · Mar 5, 2024 · PreprintBiochemistry

Shear-Mediated Platelet Microparticles Demonstrate Phenotypic Heterogeneity as to Morphology, Receptor Distribution, and Hemostatic Function

Y. Roka-Moiia, K. R. Ammann, S. Miller-Gutierrez, J. Sheriff, D. Bluestein, J. E. Italiano, R. Flaumenhaft, M. J. Slepian

This study shows that shear stress generates platelet-derived microparticles (PDMPs) with varied morphology and receptor expression, which both enhance thrombin generation and inhibit platelet aggregation.

bioRxiv · Feb 8, 2023Biochemistry

Shear-Mediated Platelet Activation is Accompanied by Unique Alterations of Platelet Lipid Profile

A. Sweedo, L. M. Wise, Y. Roka-Moiia, F. Teran Arce, S. S. Saavedra, J. Sheriff, D. Bluestein, M. J. Slepian, J. G. Purdy

This study compares lipidome changes in platelets activated by shear stress versus biochemical agents, finding unique lipid release patterns associated with shear activation.

bioRxiv · Jan 8, 2021Cell Biology