J. G. Purdy

Metabolites that feed upper glycolytic branches support glucose independent human cytomegalovirus replication

This study shows that HCMV can replicate without glucose by using metabolites from upper glycolytic pathways like the pentose phosphate pathway.

The p97-UBXD8 complex modulates ER-Mitochondria contact sites by modulating membrane lipid saturation and composition

This study shows that the p97-UBXD8 complex regulates ER-mitochondria contact sites by modulating membrane lipid saturation and composition, with implications for neurodegenerative diseases.

Human Cytomegalovirus uses a Host Stress Response to Balance the Elongation of Saturated/Monounsaturated and Polyunsaturated Very Long Chain Fatty Acids

This study shows that PERK, part of the ER stress pathway, differentially regulates fatty acid elongation enzymes to balance lipid synthesis in HCMV-infected cells, supporting viral replication.

Hypoxia-inducible factor 1α (HIF1α) Suppresses Virus Replication in Human Cytomegalovirus Infection by Limiting Kynurenine Synthesis

This study shows HIF1 suppresses HCMV replication by limiting kynurenine synthesis and AhR signaling.

Shear-Mediated Platelet Activation is Accompanied by Unique Alterations of Platelet Lipid Profile

This study compares lipidome changes in platelets activated by shear stress versus biochemical agents, finding unique lipid release patterns associated with shear activation.

Human Cytomegalovirus Remodeling of Lipid Metabolism Requires pUL37x1

This study shows that the HCMV protein pUL37x1 is required for lipid metabolism remodeling but not central carbon metabolism hijacking during infection.