Substrate-dependent accessibility changes in the Na+-dependent C4-dicarboxylate transporter, VcINDY, suggest differential substrate effects in a multistep mechanism.
C. Mulligan, C. D. D. Sampson, M. J. Stewart, J. A. Mindell
This study investigates how substrate binding affects the conformational state of VcINDY using solvent accessibility measurements, revealing substrate-specific effects on transporter dynamics.
bioRxiv · Jan 16, 2020Biochemistry