Author

C. Mulligan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Organism:E. coli· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

D.-N. Wang· 2 shared J. A. Mindell· 2 shared J. J. Marden· 2 shared J. Song· 2 shared A. Daab· 1 shared A. Leech· 1 shared A. Moores· 1 shared B. R. Streather· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiophysics

D.-N. Wang

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Author profile →

5 papers

Recent·Most cited

Structure, substrate selectivity determinants and membrane interactions of a Glutamate-specific TAXI TRAP binding protein from Vibrio cholerae.

J. F. Davies, A. Daab, N. Massouh, C. Kirkland, B. Strongitharm, A. Leech, M. Farre, G. H. Thomas, C. Mulligan

This paper structurally and biochemically characterizes a glutamate-specific TRAP transporter from V. cholerae, revealing its substrate selectivity and membrane interaction mechanisms.

bioRxiv · Mar 22, 2024 · PreprintBiochemistry

Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter

C. D. Kinz-Thompson, M. Lopez Redondo, C. Mulligan, D. B. Sauer, J. J. Marden, J. Song, E. Tajkhorshid, J. F. Hunt, D. L. Stokes, J. A. Mindell, D.-N. Wang, R. L. Gonzalez

This study uses single-molecule experiments to show that VcINDY, a sodium-coupled dicarboxylate transporter, uses stochastic elevator-like motions for substrate translocation, with non-cooperative protomer movements and cooperative binding.

bioRxiv · May 1, 2022Biophysics

Structural basis of ion - substrate coupling in the Na+-dependent dicarboxylate transporter VcINDY

D. Sauer, J. J. Marden, J. C. Sudar, J. Song, C. Mulligan, D.-N. Wang

This study reveals the structural mechanism by which VcINDY couples sodium and substrate binding through an induced-fit mechanism, showing that sodium binding stabilizes the substrate binding site.

bioRxiv · Jan 11, 2022Biophysics

Topological analysis of a bacterial DedA protein associated with alkaline tolerance and antimicrobial resistance.

H. L. Scarsbrook, R. Urban, B. R. Streather, A. Moores, C. Mulligan

The paper uses SCAM analysis to determine the topology of the bacterial DedA protein YqjA, validating a structural model and revealing its oligomeric arrangement.

bioRxiv · Oct 18, 2021Biochemistry

Substrate-dependent accessibility changes in the Na+-dependent C4-dicarboxylate transporter, VcINDY, suggest differential substrate effects in a multistep mechanism.

C. Mulligan, C. D. D. Sampson, M. J. Stewart, J. A. Mindell

This study investigates how substrate binding affects the conformational state of VcINDY using solvent accessibility measurements, revealing substrate-specific effects on transporter dynamics.

bioRxiv · Jan 16, 2020Biochemistry