Author

J. A. Mindell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

C. Mulligan· 2 shared A. Amin· 1 shared A. Becerril· 1 shared A. Nygaard· 1 shared C. D. D. Sampson· 1 shared C. D. Kinz-Thompson· 1 shared C. J. Loland· 1 shared D. B. Sauer· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiophysics

C. Mulligan

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Author profile →

4 papers

Recent·Most cited

Exploring the K+ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

S. G. Schmidt, A. Nygaard, J. A. Mindell, C. J. Loland

This study investigates how K+ binding affects substrate transport and conformational changes in LeuT, showing that K+ affinity and selectivity are influenced by mutations in the Na1 site.

bioRxiv · Apr 4, 2023Biophysics

Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter

C. D. Kinz-Thompson, M. Lopez Redondo, C. Mulligan, D. B. Sauer, J. J. Marden, J. Song, E. Tajkhorshid, J. F. Hunt, D. L. Stokes, J. A. Mindell, D.-N. Wang, R. L. Gonzalez

This study uses single-molecule experiments to show that VcINDY, a sodium-coupled dicarboxylate transporter, uses stochastic elevator-like motions for substrate translocation, with non-cooperative protomer movements and cooperative binding.

bioRxiv · May 1, 2022Biophysics

Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance

J. A. Mindell, X. Leray, J. K. Hilton, K. Nwangwu, A. Becerril, V. Mikusevic, G. Fitzgerald, A. Amin, M. R. Weston

This study shows that PI(3,5)P2 inhibits ClC-7, a chloride antiporter, which is crucial for maintaining lysosomal pH.

bioRxiv · Oct 7, 2021Biophysics

Substrate-dependent accessibility changes in the Na+-dependent C4-dicarboxylate transporter, VcINDY, suggest differential substrate effects in a multistep mechanism.

C. Mulligan, C. D. D. Sampson, M. J. Stewart, J. A. Mindell

This study investigates how substrate binding affects the conformational state of VcINDY using solvent accessibility measurements, revealing substrate-specific effects on transporter dynamics.

bioRxiv · Jan 16, 2020Biochemistry