Hydroxylation of antitubercular drug candidate, SQ109, by mycobacterial cytochrome P450
S. Bukhdruker, T. Varaksa, I. Grabovec, E. Marin, P. Shabunya, M. Kadukova, S. Grudinin, A. Kavaleuski, A. Gusach, A. Gilep, V. Borshchevskiy, N. Strushkevich
The paper shows that Mycobacterium tuberculosis CYP124 hydroxylates SQ109, a drug candidate, and potentially affects its interaction with MmpL3.
bioRxiv · Aug 27, 2020Biochemistry