MLKL D144K mutation activates the necroptotic activity of the N-terminal MLKL domain
K. Hrovat-Schaale, M. Kalic-Prolinsek, S. Hadzi, J. Lah, G. Guncar
The paper shows that the D144K mutation in MLKL removes helix H6, activating necroptotic activity by enabling oligomerization and membrane translocation.
bioRxiv · Jul 8, 2021 · PreprintBiochemistry