Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2
M. L. Bulos, E. M. Grzelak, C. Li-Ma, E. Chen, M. Hull, K. A. Johnson, M. J. Bollong
The paper identifies SM04690, a CLK2 inhibitor, as a YAP activator by promoting alternative splicing of AMOTL2, leading to reduced YAP phosphorylation and membrane localization.
bioRxiv · Apr 19, 2023 · PreprintCell Biology