M. J. Bollong

Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation

This study shows that AA147 inhibits NLRP3 inflammasome activity by covalently modifying PDIA1, suggesting PDIA1 as a therapeutic target for inflammatory diseases.

Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly.

This study identifies covalent compounds that inhibit NLRP3 inflammasome assembly by targeting reactive cysteines, suggesting NLRP3 as an electrophile sensor for inflammatory signaling.

Succinylation of a KEAP1 sensor lysine promotes NRF2 activation

The paper identifies succinylation of KEAP1 lysine 131 as a mechanism to activate NRF2 transcriptional signaling through metabolic regulation.

Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2

The paper identifies SM04690, a CLK2 inhibitor, as a YAP activator by promoting alternative splicing of AMOTL2, leading to reduced YAP phosphorylation and membrane localization.

An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

The paper identifies CCT020312, an mTOR-independent autophagy activator, which reduces tauopathy and prionopathy neurodegeneration phenotypes by enhancing autophagy flux and clearing protein aggregates.

Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer

This study shows that chronic circadian disruption increases tumor burden in KRAS-driven lung cancer by enhancing HSF1 signaling and tumorigenesis.

Metabolically Activated Proteostasis Regulators Protect Against Glutamate Toxicity by Activating NRF2

The paper shows AA147 protects neurons from glutamate toxicity by activating NRF2, highlighting its potential as a therapeutic for neurodegenerative diseases.

CRY2 missense mutations suppress P53 and enhance cell growth

The paper identifies CRY2 mutations that suppress P53 and enhance cell growth by disrupting interactions with SCFFBXL3 and affecting circadian rhythms.

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing

The paper develops a targeted RNA-seq assay to screen and deconvolute stress-responsive signaling pathway activation, demonstrating its utility for identifying selective pharmacologic activators.