M. L. Clarke

MYB insufficiency disrupts proteostasis in hematopoietic stem cells leading to age-related neoplasia

This study shows that Myb insufficiency in mice leads to age-related hematological diseases, suggesting proteostasis disruption as a mechanism.

Ablation of MYB-dependent leukaemia phenotype in MLL-driven AML correlates with increased expression of MAFB.

The paper shows that MYB ablation in MLL-driven AML increases MAFB expression, while this effect is absent in AML with complex karyotypes.