Encephalitic Alphavirus Infection Induces PARP-1 Hyperactivation Mediated Energy Collapse in Motor Neurons
Rodney Eric Williams, Lisa Pieterse, Swara S. Patel, M. L. McLaren, Matthew J. Elrick, Diane E. Griffin
This study shows that VEEV infection causes PARP-1 hyperactivation, leading to energy collapse and motor neuron death in mice and human cells.
bioRxiv · Jan 23, 2026 · PreprintMicrobiology