Author

Matthew J. Elrick

Kennedy Krieger InstituteORCID 0000-0001-7608-7593Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Diane E. GriffiniD· 1 shared Jeffrey D. RothsteiniD· 1 shared Katrina M ZinniD· 1 shared Lisa PieterseiD· 1 shared M. L. McLaren· 1 shared Malavika JayaramiD· 1 shared Mathew W McLareniD· 1 shared Michael T ImaiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMicrobiology

Diane E. GriffinORCID

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2 papers

Recent·Most cited

NeuroscienceeLifePeer-reviewedJun 18, 2026

Enterovirus D68 2A protease causes nuclear pore complex dysfunction and independently contributes to motor neuron toxicity

Katrina M Zinn, Mathew W McLaren, Michael T Imai…·Matthew J. Elrick

This study shows that EV-D68 2A protease disrupts nuclear pore complex function and causes motor neuron toxicity independently of viral replication.

DOI 10.7554/elife.108672.3

humanexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintJan 23, 2026

Encephalitic Alphavirus Infection Induces PARP-1 Hyperactivation Mediated Energy Collapse in Motor Neurons

Rodney Eric Williams, Lisa Pieterse, Swara S. Patel…·Diane E. Griffin

This study shows that VEEV infection causes PARP-1 hyperactivation, leading to energy collapse and motor neuron death in mice and human cells.

DOI 10.64898/2026.01.23.701280

𝕏 PostBluesky