The IgG3 Subclass of β1-adrenergic receptor autoantibody is an endogenous biaser of β1AR signaling
M. L. Mohan, Y. Nagatomo, S. Mukherjee, T. Engelman, R. Morales, W. H. W. Tang, S. V. Naga Prasad
This study identifies IgG3 subclass {beta}1AR autoantibodies as unique modulators of {beta}1AR signaling, biasing toward G-protein-independent ERK activation and altering {beta}-blocker responses.
bioRxiv · Sep 17, 2020Pharmacology & Toxicology