Pharmacology & ToxicologybioRxiv
The IgG3 Subclass of β1-adrenergic receptor autoantibody is an endogenous biaser of β1AR signaling
M. L. Mohan, Y. Nagatomo, S. Mukherjee…·S. V. Naga Prasad
This study identifies IgG3 subclass {beta}1AR autoantibodies as unique modulators of {beta}1AR signaling, biasing toward G-protein-independent ERK activation and altering {beta}-blocker responses.
DOI 10.1091/mbc.e20-06-0394