Author

M. Lambrughi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Organism:human· 3 Assay:protein structure· 3 Approach:statistical model· 3 Approach:biophysical modeling· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1

Frequent Co-Authors

E. Papaleo· 5 shared M. Tiberti· 3 shared A. Battistoni· 2 shared C. Pecorari· 2 shared F. Faienza· 2 shared F. Pacello· 2 shared G. Filomeni· 2 shared V. Sora· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersBiochemistry

E. Papaleo

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Author profile →

5 papers

Recent·Most cited

Decoding Phospho-Regulation and Flanking Regions in Autophagy-Associated Short Linear Motifs: A Case Study of Optineurin-LC3B Interaction

O. N. Antonescu, M. Utichi, V. Sora, M. Tiberti, E. Maiani, M. Lambrughi, E. Papaleo

This study investigates phospho-regulation and flanking regions in autophagy-related SLiMs using optineurin-LC3B as a case, revealing structural mechanisms and disease mutation impacts.

bioRxiv · Sep 30, 2023 · PreprintBiochemistry

TRAP1 S-nitrosylation as a model of population-shift mechanism to study the effects of nitric oxide on redox-sensitive oncoproteins.

E. Papaleo, M. Tiberti, M. Arnaudi, C. Pecorari, F. Faienza, L. Cantwell, K. Degn, F. Pacello, A. Battistoni, M. Lambrughi, G. Filomeni

The paper investigates how TRAP1 S-nitrosylation induces conformational changes and explores its implications for redox-sensitive oncoproteins through simulations and bioinformatics.

bioRxiv · Dec 11, 2022 · PreprintBiochemistry

S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli

F. Faienza, M. Lambrughi, S. Rizza, C. Pecorari, P. Giglio, J. Salamanca Viloria, M. F. Allega, G. Chiappetta, J. Vinh, F. Pacello, A. Battistoni, A. Rasola, E. Papaleo, G. Filomeni

This study shows that S-nitrosylation of TRAP1 at Cys501 alters its structure and ATPase activity, affecting cell response to apoptotic stimuli.

bioRxiv · Nov 30, 2019Biochemistry

The conformational and mutational landscape of the ubiquitin-like marker for the autophagosome formation in cancer

B. Aykac Fas, M. Kumar, V. Sora, M. Mashkoor, M. Lambrughi, M. Tiberti, E. Papaleo

The paper evaluates molecular dynamics models of LC3B and analyzes 26 missense mutations to understand their impact on structure and function in cancer.

bioRxiv · May 14, 2019Cancer Biology

Conformational gating in ammonia lyases

M. Lambrughi, Z. Sanader Marsic, V. Saez-Jimenez, V. Mapelli, L. Olsson, E. Papaleo

This study uses molecular dynamics to investigate conformational changes in a 3-methylaspartate ammonia lyase, showing how structural elements regulate active site accessibility.

bioRxiv · Mar 28, 2019Biophysics