J. Vinh

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

This study shows that Coxsackievirus B directly kills pancreatic β-cells and elicits weak CD8+ T-cell responses, suggesting vaccination could prevent type 1 diabetes.

Machine Learning to Predict Continuous Protein Properties from Simple Binary Sorting and Deep Sequencing Data

This paper develops a machine learning framework to predict continuous protein properties from deep sequencing data in directed evolution experiments, demonstrating its effectiveness across multiple protein engineering tasks.

Hsc70-4 mediates internalization of environmental dsRNA at the surface of Drosophila S2 cells

The paper identifies Hsc70-4 as a cell surface protein that mediates dsRNA internalization in Drosophila S2 cells, which is crucial for RNAi-based pest control.

ChipFilter: Microfluidic Based Comprehensive Sample Preparation Methodology for Metaproteomics

ChipFilter is a microfluidic method for metaproteomics that improves protein identification from microbial communities, even at low cell density.

PPP2R1A Regulates Migration Persistence through the WAVE Shell Complex

This study identifies PPP2R1A's role in migration persistence via the WAVE Shell Complex, showing its tumor suppressor function through actin regulation.

Lifestyle-specific S-nitrosylation of protein cysteine thiols regulates Escherichia coli biofilm formation and resistance to oxidative stress

This study identifies biofilm-specific S-nitrosylation in E. coli that affects redox homeostasis and oxidative stress resistance.

S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli

This study shows that S-nitrosylation of TRAP1 at Cys501 alters its structure and ATPase activity, affecting cell response to apoptotic stimuli.

Uncovering The Repertoire Of Endogenous Flaviviral Elements In Aedes Mosquito Genomes

This study identifies and characterizes endogenous flaviviral elements in Aedes mosquito genomes, revealing structural diversity and RNA-based functions.